HSPA1L Monoclonal Antibody (OTI1F12), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA812114

Catalog No. 50-168-4410

Description

In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock proteins. One class of stress proteins, termed the "small heat shock proteins" is comprised of a diverse group of proteins from ∽15 to >30kDa, with a single form found in yeast and human cells and multiple related forms found in higher plants. A direct relationship between elevated strwess protein expression and neoplasia has been suggested from studies on estrogen-induced proteins in breast cancer cells. In addition, Hsp27 exhibits rapid increased phosphorylation in response to various mitogens, turmor promoter (e.g. phorbol esters) and calcium ionophores. The expression of a 24kDa protein was shown to correlate with steroid hormone receptor in cell lines, organs, and tumors. The 24kDa estrogen-induced protein was found to be expressed at high levels in carcinoma of the breast. Another study has suggested that levels of the Hsp27 correlate with endometrial adenocarcinomas. Interestingly, the regulation of human Hsp27 by estrogens and heat shock is reminiscent of the ecdysteroid and heat shock activation of the drosophila Hsp20 genes.

Specifications

• Antigen: HSPA1L
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P34931
• Gene Symbols: HSPA1L
• Immunogen: Human recombit protein fragment corresponding to amino acids 400-641 of human HSPA1L produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI1F12
• Conjugate: Unconjugated
• Gene: HSPA1L
• Gene Alias: HSP70-1L, HSP70-HOM, HSP70T, hum70t
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3305
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid