HSPA1L Mouse anti-Human, Mouse, Rat, Clone: 3E7H2, Proteintech

Catalog No.	Quantity
50-173-7182	150 μL

Catalog No. 50-173-7182 Supplier Proteintech Group Inc Supplier No. 667801IG150UL

Description

Mouse Monoclonal Antibody

This antibody well recognizes the endogenous HSPA1L protein in multiple cell lines.

In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock proteins. One class of stress proteins, termed the "small heat shock proteins" is comprised of a diverse group of proteins from ∽15 to >30 kDa, with a single form found in yeast and human cells and multiple related forms found in higher plants. A direct relationship between elevated stress protein expression and neoplasia has been suggested from studies on estrogen-induced proteins in breast cancer cells. In addition, Hsp27 exhibits rapid increased phosphorylation in response to various mitogens, tumor promoter (e. g. phorbol esters) and calcium ionophores. The expression of a 24 kDa protein was shown to correlate with steroid hormone receptor in cell lines, organs, and tumors. The 24 kDa estrogen-induced protein was found to be expressed at high levels in carcinoma of the breast. Another study has suggested that levels of the Hsp27 correlate with endometrial adenocarcinomas. Interestingly, the regulation of human Hsp27 by estrogens and heat shock is reminiscent of the ecdysteroid and heat shock activation of the drosophila Hsp20 genes.

Specifications

• Antigen: HSPA1L
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 3E7H2
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: HSPA1L
• Gene Accession No.: P16627, P34931, P55063
• Gene Alias: Heat shock 70 kDa protein 1L, HSP70 1L, HSP70 HOM, HSP70T, HSPA1L, hum70t
• Gene Symbols: Hspa1l
• Host Species: Mouse
• Immunogen: HSPA1L Fusion Protein Ag5182
• Purification Method: Protein A
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 15482, 24963, 3305
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b