Invitrogen™ HTLV-2 env 801 Monoclonal Antibody (8.A.033)

Catalog No.	Quantity
PIMA191454	25 μg

Catalog No. PIMA191454 Supplier Invitrogen™ Supplier No. MA191454

Description

Mouse Monoclonal Antibody

MA1-91454 detects HTLV2 env 801 from human samples.

The HTLV-2 env 801 gene encodes the envelope glycoprotein, which is pivotal for virus entry into host cells. Human T-cell leukemia virus type 2 (HTLV-2) shares many structural features with HTLV-1, with the envelope (Env) protein being a critical component in mediating viral entry via interaction with cell surface receptors. The env gene product is synthesized as a precursor that is cleaved into the surface (SU) and transmembrane (TM) subunits. The SU subunit facilitates receptor binding, while the TM subunit aids in membrane fusion, enabling the virus to enter the host cell. HTLV-2 predominantly targets and transforms CD8+ T-cells, distinct from HTLV-1, which primarily transforms CD4 ⁺ T-cells. Understanding the structural and functional nuances of the HTLV-2 envelope protein is crucial as it presents a target for therapeutic interventions aimed at preventing viral entry and subsequent infection.

Specifications

• Antigen: HTLV-2 env 801
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 8.A.033
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.1M tris HCl with no preservative; pH 7.5
• Gene Alias: HTLV; HTLV2; HTLV-II
• Host Species: Mouse
• Immunogen: Highly purified HTLV-II envelope 801 antigen.
• Purification Method: Protein G
• Quantity: 25 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Virus
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a