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Invitrogen™ HTR2A Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA551349
Description
The antibody detects endogenous levels of total HTR2A / 5-HT-2A protein.
In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. The SR-2 receptors are comprised of three subtypes, SR-2A, SR-2B and SR-2C, which activate phospholipase C and release intracellular stores of calcium in response to serotonin. SR-2A has a specific role in tracheal smooth muscle contraction, bronchoconstriction and mediating aldosterone production, and it is also thought to play a role in several psychiatric disorders, including depression and schizophrenia. SR-2B is expressed in embryonic and adult cardiovascular tissues, gut and brain and plays an important role in the pathology of cardiac disorders. SR-2C is thought to mediate the effects of atypical antipsychotic drugs.
Specifications
HTR2A | |
Polyclonal | |
Unconjugated | |
Htr2a | |
5-HT-2; 5Ht-2; 5-HT2 receptor; 5-HT2A; 5-HT-2A; 5HT2A Receptor; 5-HT2A receptor; 5-HT2A/2C; 5-HT2A/2C receptor; 5-hydroxytryptamine (serotonin) receptor 2A; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; 5-hydroxytryptamine 2 receptor; 5-hydroxytryptamine receptor 2A; E030013E04; Htr2; Htr-2; HTR2A; serotonin 5HT-2 receptor; serotonin 5-HT-2A receptor; serotonin receptor 2A; SR2A | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
3356 | |
-20°C | |
Liquid |
ELISA, Immunohistochemistry (Paraffin), Western Blot | |
0.9 mg/mL | |
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4 | |
P28223 | |
Htr2a | |
Synthetic peptide of human HTR2A. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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