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Invitrogen™ HTR2C Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA533306

Catalog No. PIPA533306


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Description

Description

Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Marmoset (100%) Monkey (95%) Elephant, Panda, Horse (80%).

Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

HTR2C
Polyclonal
Unconjugated
HTR2C
5ht1c; 5-HT1C; 5-HT-1C; 5HT-1C; 5-HT1c receptor; 5-HT2C; 5-HT-2C; 5HT2C Receptor; 5-HT2C receptor; 5-HT2cR; 5HTR2C; 5-HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5-hydroxytryptamine receptor 1C; 5-hydroxytryptamine receptor 2C; HGNC:5295; HTR1C; Htr2c; RP11-810O3.1; RP23-15B7.1; serotonin 1c receptor; serotonin 5-HT-1C receptor; serotonin 5-HT-2C receptor; serotonin receptor 2C; SR1
Rabbit
Antigen affinity chromatography
RUO
3358
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin)
1 mg/mL
PBS with 0.1% sodium azide
P28335
HTR2C
Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human 5HT2C Receptor.
50 μg
Primary
Human
Antibody
IgG
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