Invitrogen™ HTRA2 Recombinant Rabbit Monoclonal Antibody (4H8C4)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA535417

Catalog No. PIMA535417

Description

Immunogen sequence: GTRSRAWLAV ALGAGGAVLL LLWGGGRGPP AVLAAVPSPP PASPRSQYNF IADVVEKTAP AVVYIEILDR HPFLGREVPI SNGSGFVVAA DGLIVTNAHV V.

The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity (1-3). Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli. This protein called Omi/HtrA2 is a mitochondrial protein that binds to IAP (4). Like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus. The deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis indicating that Omi could participate in the mitochondrial apoptotic pathway.

Specifications

• Antigen: HTRA2
• Classification: Recombinant Monoclonal
• Concentration: 0.48 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O43464, Q9JIY5
• Gene Symbols: HTRA2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human HTRA2 (O43464).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 4H8C4
• Conjugate: Unconjugated
• Gene: HTRA2
• Gene Alias: AI481710; High temperature requirement protein A2; HtrA serine peptidase 2; HtrA2; HtrA-like serine protease; mnd2; motor neuron degeneration 2; OMI; Omi stress-regulated endoprotease; PARK13; protease, serine, 25; Prss25; Serine protease 25; serine protease HTRA2, mitochondrial; serine protease OMI; serine proteinase OMI
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27429, 297376, 64704
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid