HTRA2 Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 157751AP
DescriptionThe inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity (1-3). Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli. This protein called Omi/HtrA2 is a mitochondrial protein that binds to IAP. Like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus. The deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis indicating that Omi could participate in the mitochondrial apoptotic pathway.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|HtrA serine peptidase 2, HTRA2, OMI, PARK13, PRSS25, Serine protease 25, Serine proteinase OMI|
|27429, 297376, 64704|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|HTRA2 Fusion Protein Ag8455|
|Antigen Affinity Chromatography|
|Human, Mouse, Non-human primate, Rat|
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