Gibco™ Human 4-1BB Receptor Recombinant Protein, PeproTech®

Description

Recombinant Protein

Recombinant Human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine-rich TNFR-like extracellular domain of 4-1BB Receptor. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.

Specifications

• Accession Number: Q07011
• For Use With (Application): ELISA, Functional Assay, Western Blot
• Formulation: protein with no preservative
• Gene ID (Entrez): 3604
• Molecular Weight (g/mol): 17.7 kDa
• Name: Human 4-1 BB Receptor
• Quantity: 100 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: 4 1 BB; 41 BB; 4-1 BB; 4-1 BB ligand receptor; A930040I11Rik; AA408498; AI325004; Cd137; CD137 antigen; CDw137; EGK_00183; homolog of mouse 4-1 BB; ILA; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; Ly63; receptor protein 4-1 BB; s4 1 BB; s4 1 BB; s41BB; sCD137; secreted CD137 antigen; soluble 4 1 BB; soluble 4 1 BB; soluble 41 BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1 BB; T-cell antigen 4-1 BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; TNFRSF9; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9
• Common Name: 4-1 BB (CD137)
• Gene Symbol: TNFRSF9
• Biological Activity: Determined by its inhibitory effect of the 4-1 BBL mediated stimulation of IL-8 production by human PBMC. About 90% of inhibition was seen using a concentration of 1 ug for both 4-1 BBL and 4-1 BBR.
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: MERTRSLQDP CSNCPAGTFC DNNRNQICSP CPPNSFSSAG GQRTCDICRQ CKGVFRTRKE CSSTSNAECD CTPGFHCLGA GCSMCEQDCK QGQELTKKGC KNCCFGTFND QKRGICRPWT NCSLDGKSVL VNGTKERDVV CGPSPADLSP GASSVTPPAP AREPGHS
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.