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Abnova™ Human AKT1 (NM_005163, 106 a.a. - 480 a.a) Partial Recombinant Protein with GST-His tag expressed in Sf9 cells

Used for Func, SDS-PAGE

Manufacturer:  Abnova™ P4647

Catalog No. 89-933-047


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Description

Description

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]

Specifications

Specifications

Insect cell (Sf9) expression system
0.434 ug/uL
Liquid
207
AKT1 (Human) Recombinant Protein
One-step affinity purification using GSH-agarose
100 ug
RUO
AKT1
328pmol/μg x min
Yes
NM_005163
Functional Study, Sodium Dodecyl Sulfate–Polyacrylamide Gel Electrophoresis
Liquid
77.832kDa
Insect cell (Sf9) expression system
2 ug/lane SDS-PAGE Stained with Coomassie Blue
Store at -80°C. Aliquot to avoid repeated freezing and thawing
AKT/MGC99656/PKB/PKB-ALPHA/PRKBA/RAC/RAC-ALPHA
AKT1
Insect
GST-His
SDS
Documents
Product Certifications
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