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Gibco™ Human BMP-13/CDMP-2 Recombinant Protein, PeproTech®

Catalog No. 12004500UG
Encompass_Preferred
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Quantity:
1 mg
10 μg
100 μg
250 μg
50 μg
500 μg
This item is not returnable. View return policy
This item is not returnable. View return policy

Recombinant Protein

Recombinant Human BMP-13/CDMP-2 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

GDF6 is a growth differentiation factor (GDFs), which are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. Both GDF6 and GDF7 are closely related to GDF5 which has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. In Xenopus, GDF6 is expressed at the edge of the neural plate and within the anterior neural plate including the eye fields. GDF6 is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. It may regulate patterning of the ectoderm by interacting with bone morphogenetic proteins (BMPs), and control eye development. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), a congenital disorder of spinal segmentation.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q6KF10
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 392255
Molecular Weight (g/mol) 27 kDa
Name Human BMP-13/CDMP-2
Quantity 500 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias BMP13; BMP-13; Bone morphogenetic protein 13; CDMP2; GDF16; GDF6; Gdf-6; growth differentiation factor 16; growth differentiation factor 6; growth/differentiation factor 16; Growth/differentiation factor 6; KFM; KFS; KFS1; KFSL; Klip-Feil malformation; Klippel-Feil malformation; Klippel-Feil syndrome; LCA17; MCOP4; MCOPCB6; SCDO4; SGM1
Common Name GDF6
Gene Symbol GDF6
Biological Activity The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells in the range of 2.0-3.0 ug/ml
Conjugate Unconjugated
Recombinant Recombinant
Sequence TAFASRHGKR HGKKSRLRCS KKPLHVNFKE LGWDDWIIAP LEYEAYHCEG VCDFPLRSHL EPTNHAIIQT LMNSMDPGST PPSCCVPTKL TPISILYIDA GNNVVYKQYE DMVVESCGCR
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 95% by SDS-PAGE gel and HPLC analyses.
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