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Human C-Reactive Protein (CRP) Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501572404
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50-157-2404 10 μL
50-157-2403 100 μL
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Catalog No. 50-157-2404 Supplier Bethyl Laboratories, Inc Supplier No. IHC00613T
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Description

Goat Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

CRP (C-reactive protein) is a major cyclic, pentameric acute phase protein compound consisting of five identical, noncovalently bound, nonglycosylated subunits. Eeach subunit is made up of 206 amino acids, and has a molecular weight of 24 kDa. CRP is produced by the liver, and its plasma levels rise dramatically during inflammatory processes occurring in the body. CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.), plays an important role in innate immunity, and mediates activities associated with pre-immune nonspecific host resistance. Specifically, there is a 100-1000 fold increase of CRP in response to injury, infection or inflammation. CRP is opsonic, an initiator of the classical complement cascade, and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. CRP is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host, and initiates pathogen elimination by interacting with humoral and cellular effector systems in the blood. Patients with elevated basal levels of CRP have been shown to be an increased risk for hypertension and cardiovascular disease.

Specifications

Antigen Human C-Reactive Protein (CRP)
Applications Immunohistochemistry
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene CRP
Gene Accession No. P02741
Gene Alias CRP
Gene Symbols CRP
Host Species Goat
Immunogen Human C-Reaction Protein
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1401
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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