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Invitrogen™ Human CRIM1 (aa 101-207) Control Fragment Recombinant Protein

Catalog No. RP93700
Encompass_Preferred
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Quantity:
100 μL

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (88%), Rat (88%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-51412 (PA5-51412. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

CRIM1 (cysteine-rich motor neuron 1), a glycosylated type I transmembrane protein, plays a role in tissue development i.e. capillary formation and maintenance during angiogenesis. It contains an N-terminal IGF-binding protein-like motif and six von Willebrand-like cysteine-rich repeats (CRRs) in its extracellular domain. CRIM1 interacts with BMP4 and BMP7 via the CRRs and functions as an antagonist. CRIM1 is developmentally expressed in a number of tissues including the pancreas, kidney, placenta, brain and blood vessels. CRIM1 may participate in CNS and placental development by interacting with growth factors involved in motor neuron differentiation and survival.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q9NZV1
Concentration ≥5.0 mg/mL
For Use With (Application) Blocking Assay, Control
Formulation 1 M urea, PBS with no preservative; pH 7.4
Gene ID (Entrez) 51232
Name Human CRIM1 (aa 101-207) Control Fragment
Quantity 100 μL
Regulatory Status RUO
Gene Alias AU015004; Crim1; CRIM-1; cysteine rich transmembrane BMP regulator 1; cysteine rich transmembrane BMP regulator 1 (chordin like); cysteine rich transmembrane BMP regulator 1 (chordin-like); cysteine-rich motor neuron 1; cysteine-rich motor neuron 1 protein; Cysteine-rich repeat-containing protein S52; Processed cysteine-rich motor neuron 1 protein; S52; UNQ1886/PRO4330
Common Name CRIM1
Gene Symbol CRIM1
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence LTEYEAGVCEDENWTDDQLLGFKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCEVQFSPRCPEDSVLIEGYAPPGECCPLP
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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