Invitrogen™ Human CXCL10 (IP-10) Recombinant Protein

Description

Recombinant Protein

IP10 (human) Recombinant Protein, RP-8647, from Invitrogen.

The chemokine IP-10 (or CXCL10) is a chemokine made by monocytes, endothelial cells and fibroblasts in response to treatment with IFNgamma. IP-10 functions as a chemoattractant to cells (activated T cells and NK cells) expressing the G protein-coupled receptor, CXCR3. IP-10 plays an important role in Th1 type inflammatory diseases and autoimmune diseases such as, Hashimoto′s thyroiditis, Graves′ disease and Type 1 diabetes mellitus. Recombinant human IP-10 is a non-glycosylated protein, containing 77 amino acids, with a molecular weight of 8.5 kDa. Purity is typically greater than 97% and endotoxin level less than 1 EU/ug. The expected biological activity (ED50) is determined by the ability to chemoattract human T lymphocytes at 5-40ng/mL. The specific activity of this protein is 2x10^5 units/mg. Reconstitute using sterile water at 0.1mg/mL and centrifuge prior to opening vial. Gently pipet solution down the sides of the vial. DO NOT VORTEX sample. Store reconstituted material at -20°C and add 0.1% BSA for additional stability. Amino acid sequence: VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK EMSKRSP.

Specifications

• Accession Number: P02778
• Concentration: 0.1mg/mL
• For Use With (Application): Control
• Formulation: 0.1%TFA with no preservative
• Gene ID (Entrez): 3627
• Molecular Weight (g/mol): ∽8.5
• Name: Human CXCL10
• Quantity: 25 μg
• Source: E. coli
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: H-IP-10
• Common Name: Human CXCL10
• Gene Symbol: CXCL10
• Specific Reactivity: Human
• Conjugate: Unconjugated
• Cross Reactivity: Hu
• Species: E. coli
• Recombinant: Recombinant
• Form: Lyophilized
• Protein Subtype: Recombinant
• Purity or Quality Grade: purified

in vitro research only