Invitrogen™ Human Factor X Native Protein

Description

Native Protein

RP-43072 contains native human Factor X protein purified from blood/plasma. RP-43072 may be used as a positive control in many immunological assays. The product is of human blood/plasma origin. Although the starting material was tested prior to initiation of the manufacturing process, and was found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II, extreme caution should be used when handling this material as there is a margin of error in all tests. This product is to be used for IN VITRO research purposes only, and is not intended for clinical or diagnostic use!

F10 undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.

Specifications

• Accession Number: P00742
• Concentration: 9.1 mg/mL
• For Use With (Application): Control
• Formulation: 50% water with 50% glycerol and no preservative
• Gene ID (Entrez): 2159
• Molecular Weight (g/mol): 58.9 kDa
• Name: Human Factor X
• Quantity: 100 μg
• Source: Human
• Regulatory Status: RUO
• Gene Alias: Activated factor Xa heavy chain; blood coagulation factor X; Cf10; coagulation factor 10; coagulation factor X; coagulation factor x protein; F10; Factor 10; Factor x heavy chain; Factor x light chain; factor Xa; Factor10; FX; FXA; prothrombinase; RP11-98F14.9; stuart factor; Stuart-Prower factor; Unknown (protein for IMAGE:8121240); unnamed protein product
• Common Name: Factor X
• Gene Symbol: F10
• Conjugate: Unconjugated
• Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Protein Subtype: Native