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Invitrogen™ Human Fas (TNFRSF6/CD95) Recombinant Protein, eBioscience™

Catalog No. 509250
Encompass_Preferred
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Quantity:
50 μg

Recombinant Protein

Description: Apo-1 (Fas/CD95) is a 45 kD type I transmembrane protein belonging to the TNF receptor family. A subgroup of this receptor family called 'death receptors' contain 3-4 cysteine-rich repeats in the extracellular portion and a cystoplasmic motif called the 'death domain', which is responsible for the transduction of the death signal. The death domain associates with FADD/MORT, which in turn connects to aspartate-specific proteases (Caspases) that are implicated as mediators of most types of apoptotic cell death (6-9). Purity: >95%. Molecular Weight: 60.0 kDa.

FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily. FAS also exists in a soluble form that weight approximately 26kDa. Stimulation of FAS results in aggregation of its intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC) and activation of caspases. The auto-proteolytic processing of the caspases in the complex trigger a downstream cascade that leads to apoptosis. FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full-length isoform. The Fas/Fas ligand system has been shown to play a role in a number of human diseases such as AIDS, hepatitis and cancer. It is also assumed that induction of apoptosis through FAS ligand pathway is predominantly involved in anti-viral immune responses.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P25445
For Use With (Application) Control
Formulation protein with no preservative
Gene ID (Entrez) 355
Molecular Weight (g/mol) 60 kDa
Name Human Fas (TNFRSF6/CD95)
Quantity 50 μg
Source HEK293 cells
Regulatory Status RUO
Gene Alias AI196731; ALPS1A; APO1; APO-1; Apo1 antigen; Apo-1 antigen; APO-1 cell surface antigen; Apo-1 Fas; apoptosis antigen 1; apoptosis signaling receptor FAS; apoptosis-mediating surface antigen FAS; APT1; CD95; CD95 antigen; FAS; Fas (TNF receptor superfamily member 6); Fas (TNF receptor superfamily member); Fas (TNF receptor superfamily, member 6); Fas AMA; Fas antigen; Fas antigen (ATP1); Fas cell surface death receptor; Fas receptor; FAS1; FASLG receptor; FASTM; lpr; lymphoproliferation; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000059646; TNF receptor superfamily member 6; TNFR6; Tnfrsf6; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily member 26; Tumor necrosis factor receptor superfamily, member 6
Common Name FAS (CD95)
Gene Symbol FAS
Product Type Recombinant Protein
Conjugate Unconjugated
Species Human (HEK293)
Recombinant Recombinant
Content And Storage 4°C
Expression System HEK293 cells
Form Lyophilized
Protein Subtype Recombinant
Purity or Quality Grade >95%
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WARNING: Cancer - www.P65Warnings.ca.gov
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