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Gibco™ Human IFN-beta, Animal-Free Recombinant Protein, PeproTech®

Catalog No. p-7245993
Encompass_Preferred
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Quantity:
1 mg
100 μg
20 μg
500 μg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Recombinant Protein

PeproTech's Recombinant Human IFN-beta is a 20.0 kDa protein containing 166 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P01574
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 3456
Molecular Weight (g/mol) 20 kDa
Name Human IFN-beta, Animal-Free
Quantity 100 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <0.1 EU/ μg
Gene Alias Fibroblast interferon; Ifb; IFF; IFN b; IFN β; IFNB; Ifnb1; IFNbeta; IFN-beta; IFNβ; Interferon; Interferon b; Interferon beta; interferon beta 1; interferon beta 1, fibroblast; interferon beta protein; interferon, beta 1; interferon, beta 1, fibroblast; interferon-beta; RP11-113D19.1
Common Name IFN beta
Gene Symbol Ifnb1
Biological Activity Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 0.25 ng/ml, corresponding to a specific activity of ≥ 4 x 10^6 units/mg
Conjugate Unconjugated
Recombinant Recombinant
Sequence MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 95% by SDS-PAGE gel and HPLC analyses.
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