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Human IFN gamma ELISA Standard,Invitrogen™ Non-distribution product as customer accommodation.

Recombinant Protein

Manufacturer:  Invitrogen 29831965

Catalog No. 50-112-3493


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Alert:

Contains Sodium azide


Description

Description

IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia. Description: Human IFN gamma is an ~20 kDa factor produced by activated T, B and NK cells and is an anti-viral and anti-parasitic cytokine. IFN gamma in synergy with other cytokines, such as TNF alpha, inhibits proliferation of normal and transformed cells. Immunomodulatory effects of IFN gamma are exerted on a wide range of cell types expressing the high affinity receptors for IFN-gamma. Glycosylation of IFN gamma does not affect its biological activity. Applications Reported: Recombinant Human IFN gamma ELISA Standard, Lyoph has been reported for use iin the Human IFN gamma ELISA Ready Set Go! (cat 88-7316). Applications Tested: The intended use of the Human IFN gamma RSG ELISA Lyophilized Standard is as a standard for Human IFN gamma ELISA Ready-SET-Go!® (cat. 88-7316). Typically the standard is run in a series of 7 doubling dilutions from the  ft.top ft. standard. Please refer to the Certificate of Analysis included with each ELISA set for instructions on the proper reconstitution and dilution of the lyophilized standard. Note: These are single-use vials. Use one time within 4 hours of reconstitution and discard. Reconstitute and dilute as suggested in the Certificate of Analysis or recovery may not be accurate. Source: E. coli expressed amino acids Gln24-Gln166 of mature human IFN gamma accession &Num; NM_000619.
Specifications

Specifications

P01579
Lyophilized
3458
Affinity chromatography
E. coli-expressed amino acids Gln 24-Gln 166 of mature human IFN gamma (accession # NM_000619).
RUO
Human IFN gamma ELISA Standard
Control, ELISA
Unlabeled
E. coli
Control, ELISA
protein with no preservative
Human IFN gamma ELISA Standard
4pack
4°C
Recombinant
IFNG
Human
Hu
Recombinant
Safety and Handling

Safety and Handling

ShelfLife : 12 Months

Documents
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