Invitrogen™ Human IL-31, AOF Recombinant Protein

Description

E. coli Recombinant Protein

Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.

• Purity: >95% by SDS-Page
• Endotoxin Concentration: AX41 ≤EUs/μg
• Protein Length: 141 aa.
• Biological Activity: <25 ng/mL
• Molecular Weight: 15.8 kDa
• Animal Origin Free: Yes

Specifications

• Accession Number: Q6EBC2
• For Use With (Application): Control, ELISA, Functional Assay, Western Blot
• Formulation: 20 mM sodium phosphate with 50 mM NaCl and no preservative
• Gene ID (Entrez): 386653
• Molecular Weight (g/mol): 15.8 kDa
• Name: Human IL-31, AOF
• Quantity: 500 μg
• Source: E. coli
• Storage Requirements: -20°C
• Regulatory Status: RUO
• Gene Alias: 1700013B14Rik; Il31; IL-31; ILN; Interleukin; interleukin 31; Interleukin-31
• Gene Symbol: Il31
• Specific Reactivity: Human
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Form: Lyophilized
• Purity or Quality Grade: >95%