Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Human IL-6 ELISA Standard,Invitrogen™ Non-distribution product as customer accommodation.

Recombinant Protein

Manufacturer:  Invitrogen 29806965

Catalog No. 50-112-3489


Add to cart

Alert:

Contains Sodium azide


Description

Description

Interleukin 6 (IL-6) is a multifunctional 26 kD protein originally discovered in the medium of RNA-stimulated fibroblastoid cells. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be important as IL-1 and TNF-a in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. IL-6 acts upon a variety of cells including myeloid progenitor cells, T cells, B cells, and hepatocytes. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas. Primarily produced at sites of acute and chronic inflammation, IL-6 is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of IL-6 is implicated in a wide variety of inflammation-associated disease states including diabetes mellitus and systemic juvenile rheumatoid arthritis. Description: Human IL-6 (also known as B Cell Stimulating Factor BCSF, BSF-2) is a ~21-28 kDa factor produced by a variety of cell types including monocytes, fibroblasts and endothelial cells. Upon stimulation, macrophages, T, B, mast, glial cells, eosinophils, keratinocytes and granulocytes also secrete IL-6. This pleiotrophic cytokine influences antigen-specific immune response, inflammatory response, and the development of neurons and is a major mediator of the acute phase reaction. Applications Reported: Human IL-6 RSG ELISA Lyophilized Standard has been reported for use in the Human IL-6 ELISA RSG (cat. 88-7066). Applications Tested: The intended use of the Human IL-6 RSG ELISA Lyophilized Standard is as a standard for the Human IL-6 ELISA (cat. 88-7066). Typically the standard is run in a series of 7 doubling dilutions from the  ft.top ft. standard. Please refer to the Certificate of Analysis included with each ELISA set for instructions on the proper reconstitution and dilution of the lyophilized standard. Note: These are single-use vials. Use one time within 4 hours of reconstitution and discard. Reconstitute and dilute as suggested in the Certificate of Analysis or recovery may not be accurate. Source: E. coli expressed amino acids Pro 29-Met 212 of mature human IL-6 accession &Num; AF372214.
Specifications

Specifications

P05231
Lyophilized
3569
Affinity chromatography
E. coli-expressed amino acids Pro 29-Met 212 of mature human IL-6 (accession # AF372214).
RUO
Human IL-6 ELISA Standard
Control, ELISA
Unlabeled
E. coli
Control, ELISA
protein with no preservative
Human IL-6 ELISA Standard
4pack
4°C
Recombinant
IL6
Human
Hu
Recombinant
Safety and Handling

Safety and Handling

ShelfLife : 12 Months

Documents
Provide Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit