Invitrogen™ Human LXR alpha (aa 318-329) Synthetic Peptide

Catalog No. PEP114

Supplier: Invitrogen™ PEP114

Description

Synthetic Peptide

Human LXR alpha (residues 318-329) Synthetic Peptide, PEP-114, from Invitrogen.

NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.

Specifications

• Gene ID (Entrez): 10062
• Species: Human
• Purification Method: purified
• Accession Number: Q13133
• Common Name: Human LXR alpha (aa 318-329)
• Concentration: 0.5 mg/mL
• Content And Storage: -20°C. Avoid freeze-thaw cycles.
• Description: Synthetic Peptide
• Format: Lyophilized
• Formulation: peptide with no preservative
• For Use With (Application): Control
• Gene Symbol: NR1H3
• Lyophilized: Lyophilized
• Preservative: No preservative
• Product Type: Peptide
• Quantity: 50 μg
• Regulatory Status: RUO - research use only
• Sequence: C-D318-F-S-Y-N-R-E-D-F-A-K-A(329)