Gibco™ Human Osteoprotegerin (TNFRSF11B) Recombinant Protein, PeproTech®

Description

Recombinant Protein

Recombinant Human OPG is a soluble 20.0 kDa protein containing 174 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

Specifications

• Accession Number: O00300
• For Use With (Application): ELISA, Functional Assay, Western Blot
• Formulation: protein with no preservative
• Gene ID (Entrez): 4982
• Molecular Weight (g/mol): 20 kDa
• Name: Human Osteoprotegerin (TNFRSF11B)
• Quantity: 100 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 11 B; MGC29565; OCIF; Opg; osteoclastogenesis inhibitory factor; Osteoprotegerin; PDB5; soluble OPG; soluble Osteoprotegerin; sOPG; TNF receptor superfamily member 11 b; TNFRSF11B; TR1; tumor necrosis factor receptor superfamily member 11 B; tumor necrosis factor receptor superfamily, member 11 b; tumor necrosis factor receptor superfamily, member 11 b (osteoprotegerin)
• Common Name: TNFRSF11B
• Gene Symbol: TNFRSF11B
• Biological Activity: Determined by its ability to inhibit TRAIL-induced apoptosis of LN-18 glioblastoma cells.
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: METFPPKYLH YDEETSHQLL CDKCPPGTYL KQHCTAKWKT VCAPCPDHYY TDSWHTSDEC LYCSPVCKEL QYVKQECNRT HNRVCECKEG RYLEIEFCLK HRSCPPGFGV VQAGTPERNT VCKRCPDGFF SNETSSKAPC RKHTNCSVFG LLLTQKGNAT HDNICSGNSE STQK
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.