Abnova™ Human PLAU (high molecular weight) native Protein from human urine

Description

Used for SDS-PAGE

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Specifications

• Concentration: 3.27 mg/mL
• For Use With (Application): SDS-PAGE
• Formulation: In 0.05M sodium acetate, 0.1M NaCl, pH 5.0 (1mM EDTA)
• Gene ID (Entrez): 5328
• Molecular Weight (g/mol): 54kDa
• Name: PLAU (Human) Native Protein
• Preparation Method: Native protein purified from human urine
• Purification Method: Column chromatography using several resins
• Quantity: 100 μg
• Storage Requirements: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
• Regulatory Status: RUO
• Gene Alias: ATF/UPA/URK/UROKINASE/u-PA
• Common Name: PLAU
• Gene Symbol: PLAU
• Species: Human
• Protein Tag: None
• Expression System: Native protein purified from human urine
• Form: Liquid
• Purity or Quality Grade: >95% by SDS-PAGE