Abnova™ Human TNFSF11 (O14788, 174 amino acids) Partial Recombinant Protein

Description

Used for Func, SDS-PAGE

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq]

Specifications

• Accession Number: O14788
• For Use With (Application): Functional Study, SDS-PAGE
• Formulation: Lyophilized
• Gene ID (Entrez): 8600
• Molecular Weight (g/mol): 20kDa
• Name: TNFSF11 (Human) Recombinant Protein
• Preparation Method: Escherichia coli expression system
• Quantity: 10 μg
• Storage Requirements: Store at -20°C on dry atmosphere. After reconstitution with 5 mM Tris, pH 7.5, store at -20°C. Aliquot to avoid repeated freezing and thawing.
• Regulatory Status: RUO
• Endotoxin Concentration: <0.1ng/μg
• Gene Alias: CD254/ODF/OPGL/OPTB2/RANKL/TRANCE/hRANKL2/sOdf
• Common Name: TNFSF11
• Gene Symbol: TNFSF11
• Biological Activity: Determined by its ability to neutralize the stimulation of U937 cells treated with 10ng/mL of sRANKL.
• Species: E. coli
• Recombinant: Recombinant
• Protein Tag: None
• Expression System: Escherichia coli expression system
• Form: Lyophilized
• Purity or Quality Grade: ≥98% by SDS-PAGE and HPLC