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Invitrogen™ TRAIL Human ELISA Kit Non-distribution product as customer accommodation.

For the quantitative detection of human TRAIL.

Manufacturer:  Invitrogen™ BMS2004TEN

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Catalog No. 50-178-66


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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human TRAIL
Biotin-Conjugate anti-human TRAIL monoclonal antibody
Streptavidin-HRP
Human TRAIL Standard lyophilized, 2ng/mL upon reconstitution
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films

Description

Description

TRAIL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TRAIL preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. TRAIL binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of TRAIL protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Receptors for TRAIL include two death domain containing receptors, death receptor 4 (DR4) and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. TRAIL is a type II membrane protein and expressed in a variety of human tissues. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.
Specifications

Specifications

Biotin
HRP
15.6-1,000 pg/mL
8743
RUO
2°C to 8°C
3 hr. 20 min.
TNF-related apoptosis-inducing ligand
6.5%
Human
5.0 pg/mL
Colorimetric Microplate Reader
ELISA Kit
P50591
ELISA
Pre-coated 96 well plate, Standard, Sample Diluent, Assay Buffer concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
Plasma, 50 μL|Serum, 50 μL|Supernatant, 50 μL
1 hr. 20 min.
Human
7.7%
10 x 96 Tests
Plasma, Serum, Supernatant
APO2L,Apo-2L,CD253,TL2,TNLG6A,TRAIL
SDS
Documents
Product Certifications
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