Invitrogen™ Human TRAIL (TNFSF10) Recombinant Protein, eBioscience™

Description

Recombinant Protein

Description: Human TRAIL (TNF-Related Apoptosis Inducing Ligand), also called Apo2 Ligand, is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. Human TRAIL/Apo2 Ligand is a 19.6 kDa protein, comprising the full-length of the TNF-like extracellular domain of TRAIL. Purity: >97%. Molecular Weight: 19.6 kDa.

TRAIL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TRAIL preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. TRAIL binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of TRAIL protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Receptors for TRAIL include two death domain containing receptors, death receptor 4 (DR4) and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. TRAIL is a type II membrane protein and expressed in a variety of human tissues. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.

Specifications

• Accession Number: P50591
• For Use With (Application): Control
• Formulation: PBS with no preservative; pH 7.4
• Gene ID (Entrez): 8743
• Molecular Weight (g/mol): 19.6 kDa
• Name: Human TRAIL (TNFSF10)
• pH Range: 7.4
• Quantity: 50 μg
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: A330042I21Rik; AI448571; Apo-2 ligand; APO2L; Apo-2 L; CD253; CD253 antigen; chemokine tumor necrosis factor ligand superfamily member 10; Ly81; Protein TRAIL; TL2; TN; TNF superfamily member 10; TNF-related apoptosis inducing ligand; TNF-related apoptosis inducing ligand TRAIL; TNF-related apoptosis-inducing ligand; Tnfsf10; TNLG6A; TRAIL; TRAIL protein; TRAIL/APO2L; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor (ligand) superfamily member 10; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta; tumor necrosis factor ligand 6 A; tumor necrosis factor ligand superfamily member 10; tumor necrosis factor superfamily member 10
• Common Name: TRAIL (CD253)
• Gene Symbol: TNFSF10
• Product Type: Recombinant Protein
• Conjugate: Unconjugated
• Species: E. coli
• Recombinant: Recombinant
• Sequence: Human TRAIL (TNFSF10) recombinant protein comprises the full-length of the extracellular domain of human TRAIL
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Protein Subtype: Recombinant
• Purity or Quality Grade: >97%

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov