Abnova™ Human ZAP70 (P43403) Full-length Recombinant Protein with GST expressed in Sf9 cells

Description

Used for Func, SDS-PAGE

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq]

Specifications

• Accession Number: P43403
• For Use With (Application): Functional Study, SDS-PAGE
• Formulation: Liquid
• Gene ID (Entrez): 7535
• Molecular Weight (g/mol): 96kDa
• Name: ZAP70 (Human) Recombinant Protein
• Quality Control Testing: 3 ug/lane SDS-PAGE Stained with Coomassie Blue
• Quantity: 5 ug
• Storage Requirements: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
• Regulatory Status: RUO
• Gene Alias: FLJ17670/FLJ17679/SRK/STD/TZK/ZAP-70
• Common Name: ZAP70
• Gene Symbol: ZAP70
• Biological Activity: 113nmol phosphate incorporated into Poly(Glu-Tyr) substrate per minute per mg protein at 30°C for 15 minutes using a final concentration of 50μM ATP (0.83 uCi/assay in 25μL reaction volume).
• Species: Baculovirus
• Recombinant: Recombinant
• Protein Tag: GST
• Form: Liquid
• Purity or Quality Grade: ≥90% by SDS-PAGE