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Abnova™ Human ZAP70 (P43403) Full-length Recombinant Protein with GST expressed in Sf9 cells

Used for Func, SDS-PAGE

Manufacturer:  Abnova™ P4235

Catalog No. 89-967-662


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Description

Description

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq]

Specifications

Specifications

P43403
Liquid
7535
ZAP70 (Human) Recombinant Protein
3 ug/lane SDS-PAGE Stained with Coomassie Blue
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
FLJ17670/FLJ17679/SRK/STD/TZK/ZAP-70
ZAP70
Insect
GST
Functional Study, Sodium Dodecyl Sulfate–Polyacrylamide Gel Electrophoresis
Liquid
96kDa
≥90% by SDS-PAGE
5 ug
RUO
ZAP70
113nmol phosphate incorporated into Poly(Glu-Tyr) substrate per minute per mg protein at 30°C for 15 minutes using a final concentration of 50μM ATP (0.83 uCi/assay in 25μL reaction volume).
Yes
SDS
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