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Invitrogen™ Humanin Polyclonal Antibody
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Catalog No. PA14358
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100 μg
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Catalog No. Quantity
PA14358 100 μg
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Catalog No. PA14358 Supplier Invitrogen™ Supplier No. PA14358
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Description

Rabbit Polyclonal Antibody

PA1-4358 detects Humanin from human samples. PA1-4358 has been successfully used in Western blot procedures. The PA1-4358 immunogen is a synthetic peptide corresponding to residues L(9) L L L T S E I D L P V K R R A(24) of human Humanin.

Humanin is a novel 24 A. A polypeptide identified in Alzheimer's disease-affected brain. It is 99% homologous to mitochondrial 16s ribosomal RNA and functions as a novel neuroprotective and cytoprotective factor. It specifically inhibits neuronal cell death induced by beta-amyloids and Alzheimer's disease causing FAD genes by competitively inhibiting access of FPRL1 receptor to beta-amyloids. It acts as an anti-apoptotic factor by binding to Bcl-2/Bax family of pro-apoptotic factors including Bax, Bak, Bid and BimEL and inhibits their pro-apoptotic activity. It activates JAK/STAT signaling pathway and is regulated by TRIM11. It interacts with IGFBP-3 and specifically blocks IGFBP-3 induced cell death in glioblastoma cells. Humanin is also expressed in colon and testis.
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Specifications

Antigen Humanin
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene MT-RNR2
Gene Accession No. Q8IVG9
Gene Alias BCL2L4; HN1; Humanin-like 1; humanin-like protein 1; mitochondrially encoded 16S RNA; MTRNR2; MT-RNR2; MTRNR2L1; MT-RNR2-like 1; MTRNR2-like 1; MT-RNR2-like protein 1; RNR2
Gene Symbols MT-RNR2
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues L(9) L L L T S E I D L P V K R R A(24) of human Humanin.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4550
Target Species Human
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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