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humanin Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501735114 Shop All Proteintech Group Inc Products
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50-173-5114 150 μL
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Catalog No. 50-173-5114 Supplier Proteintech Group Inc Supplier No. 258861AP150UL
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Description

Rabbit Polyclonal Antibody

Humanin is a novel 24 A. A polypeptide identified in Alzheimer′s disease-affected brain. It is 99% homologous to mitochondrial 16s ribosomal RNA and functions as a novel neuroprotective and cytoprotective factor. It specifically inhibits neuronal cell death induced by beta-amyloids and Alzheimer′s disease causing FAD genes by competitively inhibiting access of FPRL1 receptor to beta-amyloids. It acts as an anti-apoptotic factor by binding to Bcl-2/Bax family of pro-apoptotic factors including Bax, Bak, Bid and BimEL and inhibits their pro-apoptotic activity. It activates JAK/STAT signaling pathway and is regulated by TRIM11. It interacts with IGFBP-3 and specifically blocks IGFBP-3 induced cell death in glioblastoma cells. Humanin is also expressed in colon and testis.

Specifications

Antigen humanin
Applications Flow Cytometry, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.23 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene MT-RNR2
Gene Accession No. Q8IVG9
Gene Alias humanin, l rRNA, MTRNR2, RNR2
Gene Symbols MT-RNR2
Host Species Rabbit
Immunogen Peptide
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4550
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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