Huntingtin Polyclonal Antibody, Bethyl Laboratories

Catalog No.	Quantity
50-156-3544	20 μL

Catalog No. 50-156-3544 Supplier Bethyl Laboratories, Inc Supplier No. A302812AT

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

Huntington′s disease (HD) is a neurodegenerative disorder caused by an expanding polyglutamine repeat in the huntingtin gene. HD is a mid-life onset autosomal domit neurodegenerative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years. The HD gene product is widely expressed in human tissues, with the highest level of expression in the brain. The huntington gene product is expressed at similar levels in patients and controls, which suggests that the expansion of the polyglutamine repeat induces a toxic gain of function perhaps through interactions with other cellular proteins. Using yeast two-hybrid system Li et al., have identified a protein, HAP1 (huntington associated protein 1), that associates with huntingtin protein. The in vitro data suggest that the association between HAP1 and huntington is enhanced by increasing length of glutamine repeat.

Specifications

• Antigen: Huntingtin
• Applications: Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene: HTT
• Gene Accession No.: P42858
• Gene Alias: HD, IT15
• Gene Symbols: HTT
• Host Species: Rabbit
• Immunogen: Between 1150 and 1200
• Purification Method: Antigen affinity chromatography
• Quantity: 20 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3064
• Target Species: Human
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG