Invitrogen™ HVCN1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA558737

Catalog No. PIPA558737

Description

Immunogen sequence: GIIISVKTRS ERQLLRLKQM NVQLAAKIQH LEFSCSEKEQ EIERLNKLLR QHGLLGEVN Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 86%.

HVCN1 (hydrogen voltage-gated channel 1), a voltage gated proton channel protein that is highly expressed in immune tissues, mediates the proton conductances required by phagocytic leukocytes for the oxidative burst that underlies microbial killing. HVCN1 moderates the voltage-dependent proton permeability of excitable membranes by allowing the flow of protons in accordance to their electrochemical gradient. HVCN1 is sensitive to zinc ions, and can be inhibited by them. HVCN1 may represent a new therapeutic target for B cell malignancies on continued signaling via the B cell antigen receptor.

Specifications

• Antigen: HVCN1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HVCN1
• Gene Alias: 0610039P13Rik; AI450555; BTS; HV1; Hvcn1; hydrogen voltage gated channel 1; hydrogen voltage-gated channel 1; mVSOP; RGD1310788; UNQ578/PRO1140; Voltage sensor domain-only protein; voltage-gated hydrogen channel 1; Vsop; Vsop.
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84329
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96D96
• Gene Symbols: HVCN1
• Immunogen: Recombinant protein corresponding to Human HVCN1. Recombinant protein control fragment (Product #RP-91100).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG