Invitrogen™ HYD Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589459

Catalog No. PIPA589459

Description

Immunogen sequence: SISAGIPKVG VLMESVWNMN DSCRFQLRSP ESLKNMEKAS KTTEAKPESK QEPVKTEMGP PPSPASTCSD ASSIASSASM PYKRRRSTPA PKEEEKVNEE QWSLREVVFV EDVKNVPVGK VLKVDGAYVA VKFPGTSSNT NCQNSSGPDA DPSSLLQDCR LLRIDELQVV KTGGTPKVPD CFQRTPKKLC IPEKTEILAV NVDSKGVHAV L; Positive Samples: U-87MG, 293T, Jurkat, HeLa; Cellular Location: Nucleus.

EDD (for E3 identified by Differential Display) is a progestin-regulated gene that was isolated from T-47D human breast cancer cells. Based on sequence homology, EDD appears to be a human homolog of the Drosophila hyperplastic discs (hyd) gene, a tumor suppressor gene that is required for control of imaginal disc growth. EDD contains a HECT domain in the carboxy terminus. HECT domain-containing proteins function as ubiquitin-protein ligases, or E3 enzymes. EDD has been shown to bind to ubiquitin, and like other HECT family proteins, may function as an E3 ubiquitin-protein ligase.

Specifications

• Antigen: HYD
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UBR5
• Gene Alias: CH D1S3362; DD5; E3 identified by differential display; E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase, HECT domain-containing 1; ECGF1; Edd; Edd1; EDG1; EDG-1; extraembryonic development; HECT-type E3 ubiquitin transferase UBR5; hHYD; HYD; Hyperplastic discs protein homolog; KIAA0896; Progestin-induced protein; Rat100; S1P receptor 1; S1P receptor Edg-1; S1P1; S1PR1; ubiquitin protein ligase E3 component n-recognin 5; Ubr5
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51366
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.92 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O95071
• Gene Symbols: UBR5
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 550-760 of human UBR5 (NP_0569862).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG