Invitrogen™ Hydromorphone Polyclonal Antibody

Sheep Polyclonal Antibody

Supplier:  Invitrogen™ PA175167

Catalog No. PIPA175167

Description

Working Concentration: 1.25 μg/mL. Sensitivity: 10 ng/mL Hydromorphone produces 74% inhibition in a competitive ELISA employing Hydromorphone polyclonal antibody.

Hydromorphone Base is the hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons.

Specifications

• Antigen: Hydromorphone
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Alias: C17H19NO3; Dihydromorfinon; Dihydromorphinone; Dilaudid; Dimorphone; Idromorfone
• Immunogen: Hydromorphone(3)-BTG.
• Quantity: 1 mg
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Target Molecule: Chemical

• Applications: ELISA
• Concentration: 7.28 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.8
• Host Species: Sheep
• Purification Method: purified
• Regulatory Status: RUO
• Target Species: Chemical
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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