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Invitrogen™ HYOU1 Monoclonal Antibody (6E3-2C3), APC
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Catalog No. PIMA545338
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100 μg
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PIMA545338 100 μg
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Catalog No. PIMA545338 Supplier Invitrogen™ Supplier No. MA545338
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Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-45338 was sufficient for detection of GRP170 in 20 μg of HEK293 lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 170kDa.

HYOU1 belongs to the heat shock protein 70 family. The protein is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HYOU1
Applications Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 6E3-2C3
Concentration 1 mg/mL
Conjugate APC
Formulation 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
Gene HYOU1
Gene Accession No. Q63617, Q9JKR6, Q9Y4L1
Gene Alias 140 kDa Ca(2+)-binding protein; 150 kDa oxygen-regulated protein; 150-kDa oxygen regulated protein; 170 kDa glucose regulated protein GRP170; 170 kDa glucose-regulated protein; AI415631; Cab140; calcium binding protein 140; calcium binding protein, 140 kDa; CBP-140; DKFZp686N08236; FLJ94899; FLJ97572; Grp 170; Grp170; GRP-170; HSP 12A; HSP12A; HYOU1; hypoxia up-regulated 1; hypoxia up-regulated protein 1; Orp 150; Orp150; ORP-150; oxygen regulated protein (150kD)
Gene Symbols HYOU1
Host Species Mouse
Immunogen Recombinant Full length GRP170 Protein.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10525, 12282, 192235
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2b
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