Invitrogen™ I-Ab/I-Ad Monoclonal Antibody (25-9-17S), Biotin

Catalog No.	Quantity
PIMA517775	100 μg

Catalog No. PIMA517775 Supplier Invitrogen™ Supplier No. MA517775

Description

Mouse Monoclonal Antibody

MA5-17775 targets I-Ab/I-Ad in FACS applications and shows reactivity with Mouse samples. The MA5-17775 immunogen is c3H.SW splenocytes.

MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC class II. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Specifications

• Antigen: I-Ab/I-Ad
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: 25-9-17S
• Concentration: 0.1 mg/mL
• Conjugate: Biotin
• Formulation: PBS with 4-5mg/mL BSA and 0.02% sodium azide
• Gene: H2-Ab1
• Gene Accession No.: P01921, P06342, P06343, P06344, P06345, P06346, P14483
• Gene Alias: Abeta; AI845868; H-2 class II histocompatibility antigen, A beta chain; H-2Ab; H2-Ab; H2-Ab1; H2-iabeta; histocompatibility 2, class II antigen A, beta 1; Ia2; Ia-2; IAb; I-Abeta; major histocompatibility complex class II beta chain; MHC class II antigen A beta; MHC class II H2-IA-beta-psi; response to metastatic cancers 1; Rmcs1
• Gene Symbols: H2-Ab1
• Host Species: Mouse
• Immunogen: C3H.SW splenocytes.
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 14961
• Target Species: Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a