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Invitrogen™ I-Ad Monoclonal Antibody (34-5-3S), FITC
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Catalog No. PIMA517779
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100 μg
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PIMA517779 100 μg
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Catalog No. PIMA517779 Supplier Invitrogen™ Supplier No. MA517779
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Description

Mouse Monoclonal Antibody

MA5-17779 targets I-Ad in FACS applications and shows reactivity with Mouse samples. The MA5-17779 immunogen is bDF splenocytes.

MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC class II. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
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Specifications

Antigen I-Ad
Applications Flow Cytometry
Classification Monoclonal
Clone 34-5-3S
Concentration 0.1 mg/mL
Conjugate FITC
Formulation PBS with 4-5mg/mL BSA and 0.02% sodium azide
Gene H2-Ab1
Gene Accession No. P01921, P06342, P06343, P06344, P06345, P06346, P14483
Gene Alias Abeta; AI845868; H-2 class II histocompatibility antigen, A beta chain; H-2Ab; H2-Ab; H2-Ab1; H2-iabeta; histocompatibility 2, class II antigen A, beta 1; Ia2; Ia-2; IAb; I-Abeta; major histocompatibility complex class II beta chain; MHC class II antigen A beta; MHC class II H2-IA-beta-psi; response to metastatic cancers 1; Rmcs1
Gene Symbols H2-Ab1
Host Species Mouse
Immunogen BDF splenocytes.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14961
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Product Type Antibody
Form Liquid
Isotype IgG2a
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