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Invitrogen™ IA-1 Polyclonal Antibody
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Catalog No. PIPA520823
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100 μg
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Catalog No. Quantity
PIPA520823 100 μg
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Catalog No. PIPA520823 Supplier Invitrogen™ Supplier No. PA520823
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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat thymus tissue lysate. PA5-20823 can be used with blocking peptide PEP-0937.

IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.
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Specifications

Antigen IA-1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene INSM1
Gene Accession No. Q01101, Q63ZV0
Gene Alias IA1; IA-1; INSM transcriptional repressor 1; Insm1; insulinoma associated 1; insulinoma-associated 1; insulinoma-associated protein (IA-1); insulinoma-associated protein 1; insulinoma-associated protein 1-like; LOC100912563; Zinc finger protein IA-1
Gene Symbols INSM1
Host Species Rabbit
Immunogen A 19 amino acid peptide from near the amino terminus of human IA-1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100912563, 3642, 53626
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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