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Invitrogen™ IA-1 Polyclonal Antibody
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Catalog No. PIPA5107148
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PIPA5107148 100 μL
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Catalog No. PIPA5107148 Supplier Invitrogen™ Supplier No. PA5107148
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Description

Rabbit Polyclonal Antibody

Sequence homology: Cow: 86%; Dog: 92%; Horse: 85%; Human: 100%; Pig: 92%.

IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.
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Specifications

Antigen IA-1
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
Gene INSM1
Gene Accession No. Q01101
Gene Alias IA1; IA-1; INSM transcriptional repressor 1; Insm1; insulinoma associated 1; insulinoma-associated 1; insulinoma-associated protein (IA-1); insulinoma-associated protein 1; insulinoma-associated protein 1-like; LOC100912563; Zinc finger protein IA-1
Gene Symbols INSM1
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C-terminal region of human INSM1.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3642
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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