Invitrogen™ IARS2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA555117

Catalog No. PIPA555117

Description

Immunogen sequence: VASQHNLPMD CLVDEDGVFT DVAGPELQNK AVLEEGTDVV IKMLQTAKNL LKEEKLVHSY PYDWRTKKPV VIRASKQWFI NITDIKTA Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 81%.

The Trip230 gene encodes a protein of 1,978 amino acids with an estimated molecular mass of 230 kDa. The gene is located on chromosome 14q31, which is in a region associated with genetic alterations and thyroid hormone response abnormalities. The Trip230 protein interacts with Rb and thyroid hormone receptor (TR) using two distinct domains. Complex formation with Rb is in a hormone independent manner, but when Trip230 forms a complex with TR, it is in a thyroid hormone-dependent manner. After T3 treatment, Trip230 is phosphorylated and transported to the nucleus, suggesting that phosphorylation may be important for its nuclear translocation.

Specifications

• Antigen: IARS2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IARS2
• Gene Alias: 2010002H18Rik; C79125; CAGSSS; EC 6.1.1.5; Iars2; IleRS; isoleucine tRNA ligase 2, mitochondrial; isoleucine--tRNA ligase, mitochondrial; isoleucine-tRNA synthetase 2, mitochondrial; Isoleucyl-tRNA synthetase; isoleucyl-tRNA synthetase 2, mitochondrial; isoleucyl-tRNA synthetase, mitochondrial; mitochondrial isoleucine tRNA synthetase; RGD1311857
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55699
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9NSE4
• Gene Symbols: IARS2
• Immunogen: Recombinant protein corresponding to Human IARS2. Recombinant protein control fragment (Product #RP-94007).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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