Invitrogen™ Ibritumomab Recombinant Mouse Monoclonal Antibody

Mouse Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542307

Catalog No. PIMA542307

Description

Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.

Ibritumomab is a monoclonal antibody directed against the CD20 antigen found on pre-B and mature B lymphocytes (normal and malignant). Ibritumomab binding induces apoptosis in B lymphocytes in vitro. It is combined with the chelator tiuxetan, which acts as a specific chelation site for Yttrium-90 (Y-90). The monoclonal antibody acts as a delivery system to direct the radioactive isotope to the targeted cells, however, binding has been observed in lymphoid cells throughout the body and in lymphoid nodules in organs such as the large and small intestines. beta-emission induces cellular damage through the formation of free radicals (in both target cells and surrounding cells).

Specifications

• Antigen: Ibritumomab
• Classification: Recombinant Monoclonal
• Conjugate: Unconjugated
• Gene Alias: MS4A-1
• Immunogen: Human MS4A1(CD20,MS4A-1).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Target Molecule: Chemical

• Applications: ELISA
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a