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  5. Tocris Bioscience™ ICA 069673

Tocris Bioscience™ ICA 069673
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Catalog No. 430525
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25 mg
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Catalog No. Quantity
43-052-5 25 mg
43-055 5 mg
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Catalog No. 43-052-5 Supplier Tocris Bioscience™ Supplier No. 4305/25
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Description

KV7.2/KV7.3 channel opener

ICA 069673 is a selective KV7.2/KV7.3 (KCNQ2/3) channel opener (EC50 = 0.69 μM). Exhibits 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.

Specifications

Chemical Name or Material N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
CAS 582323-16-8
Assay Percent Range >99%
Quantity 25 mg
Molecular Formula C11H6ClF2N3O
Formula Weight Observed MW: 269.63
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