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Invitrogen™ ICAM-1 Polyclonal Antibody, Biotin
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Catalog No. PIPA129968
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250 μL
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PIPA129968 250 μL
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Catalog No. PIPA129968 Supplier Invitrogen™ Supplier No. PA129968
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Description

Rabbit Polyclonal Antibody

PA1-29968 detects ICAM1 from human, rhesus and cynomolgus monkey, baboon, an chimpanzee samples.

ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ICAM-1
Applications Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Biotin
Formulation PBS with 0.1% BSA and 0.02% sodium azide
Gene ICAM1
Gene Accession No. P05362, Q28806
Gene Alias BB2; CD54; cell surface glycoprotein P3.58; Human rhinovirus receptor; ICAM; Icam1; ICAM-1; ICAM-1; CD54 homolog; Intercellular adhesion molecule 1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; intercellular adhesion molecule-1; intercellular adhesion molecule-1 precursor; Ly 47; Ly-47; major group rhinovirus receptor; MALA2; MALA-2; MyD10; P3.58; sCD54; soluble CD54; Surface antigen of activated B cells
Gene Symbols ICAM1
Host Species Rabbit
Immunogen Full length protein (Human).
Purification Method IgG fraction
Quantity 250 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 101021731, 3383, 450196
Target Species Baboon, Chimpanzee, Human, Monkey
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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