Invitrogen™ ICAM-3 Monoclonal Antibody (ICAM3.1)

Catalog No.	Quantity
PIMA190977	100 μg

Catalog No. PIMA190977 Supplier Invitrogen™ Supplier No. MA190977

Description

Mouse Monoclonal Antibody

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.

Specifications

• Antigen: ICAM-3
• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, Radioimmune Assays (RIA), Western Blot
• Classification: Monoclonal
• Clone: ICAM3.1
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative
• Gene: ICAM3
• Gene Accession No.: P32942
• Gene Alias: CD50; CDw50; ICAM3; ICAM-3; ICAM-R; Intercellular adhesion molecule 3; intercellular adhesion molecule-3
• Gene Symbols: ICAM3
• Host Species: Mouse
• Immunogen: ICAM 3Fc chimeric fusion protein.
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3385
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1