Invitrogen™ ICAM-3 Monoclonal Antibody (MEM-171), Biotin

Catalog No.	Quantity
01-676-242	100 μg

Catalog No. 01-676-242 Supplier Invitrogen™ Supplier No. MA119508

Description

Mouse Monoclonal Antibody

This antibody recognizes an extracellular epitope in the D2 domain of CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes.

CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.

Specifications

• Antigen: ICAM-3
• Applications: Flow Cytometry, Immunoprecipitation
• Classification: Monoclonal
• Clone: MEM-171
• Concentration: 1 mg/mL
• Conjugate: Biotin
• Formulation: PBS with 15mM sodium azide; pH 7.4
• Gene: ICAM3
• Gene Accession No.: P32942
• Gene Alias: CD50; CDw50; ICAM3; ICAM-3; ICAM-R; Intercellular adhesion molecule 3; intercellular adhesion molecule-3
• Gene Symbols: ICAM3
• Host Species: Mouse
• Immunogen: Human granulocytes.
• Purification Method: Size-exclusion chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3385
• Target Species: Human
• Content And Storage: 4°C, do not freeze
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1