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ICI 182,780, Tocris Bioscience™

Catalog Number 10471
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Quantity:
1 mg
10 mg
50 mg
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129453-61-8
C32H47F5O3S
606.777
VWUXBMIQPBEWFH-WCCTWKNTSA-N
fulvestrant, faslodex, fulvestrant usan, faslodex tn, fulvestrant faslodex, chembl1358, fulvestrant jan/usan/inn, faslodex ici 182,780, 7r,8r,9s,13s,14s,17s-13-methyl-7-9-4,4,5,5,5-pentafluoropentylsulfinyl nonyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta a phenanthrene-3,17-diol, 7alpha-9-4,4,5,5,5-pentafluoropentyl sulfinyl nonyl estra-1,3,5 10-triene-3,17beta-diol
104741
(7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F
This item is not returnable. View return policy
129453-61-8
C32H47F5O3S
606.777
VWUXBMIQPBEWFH-WCCTWKNTSA-N
fulvestrant, faslodex, fulvestrant usan, faslodex tn, fulvestrant faslodex, chembl1358, fulvestrant jan/usan/inn, faslodex ici 182,780, 7r,8r,9s,13s,14s,17s-13-methyl-7-9-4,4,5,5,5-pentafluoropentylsulfinyl nonyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta a phenanthrene-3,17-diol, 7alpha-9-4,4,5,5,5-pentafluoropentyl sulfinyl nonyl estra-1,3,5 10-triene-3,17beta-diol
104741
(7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F

Description

Estrogen receptor antagonist

ICI 182,780 is a high affinity estrogen receptor antagonist (IC50 = 0.29 nM), devoid of any partial agonism both in vitro and in vivo. ICI 182,780 is a high affinity agonist at the membrane estrogen receptor GPER. ICI 182,780 inhibits MCF-7 human breast cancer cell growth in vitro and shows antitumor activity in mice models. ICI 182,780 penetrates the blood-brain-barrier and has neuronal functional effects in vivo.
Quantity 1 mg
Formula Weight 606.77
Percent Purity >99%
Chemical Name or Material ICI 182, 780

Safety and Handling

Recommended Storage Store at Room Temperature
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