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ICOS (CD278) Armenian Hamster, anti-Human, R718, Clone: 398.4A, BD Horizon™

Catalog No. BDB566991 Shop All BD Biosciences Products
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BDB566991 25 μg
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Catalog No. BDB566991 Supplier BD Biosciences Supplier No. 566991
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Description

Armenian Hamster Monoclonal Antibody

The C398.4A monoclonal antibody specifically binds to Inducible Costimulator (ICOS), which is also known as, CD278, Activation-inducible lymphocyte immunomediatory molecule (AILIM), or H4. ICOS is a type I transmembrane glycoprotein that forms a disulfide-linked homodimer and belongs to the CD28 family within the Ig superfamily. ICOS is expressed on either CD4+ or CD8+ single-positive mature thymocytes, T cells, or subsets of Innate Lymphoid Cells (ILC). Its expression is upregulated on activated T lymphocytes. ICOS is a costimulatory receptor that can bind to the B7-H2 ligand (CD275, ICOS-L) that is expressed on B cells, monocytes, macrophages, dendritic cells, and endothelial cells. ICOS plays a critical role in many types of T cell-dependent immunity. In the case of humoral immunity, for example, ICOS signaling is critical for the differentiation of T follicular helper (Tfh) cells and development of germinal centers. Although C398.4A was generated against mouse ICOS, this antibody reportedly crossreacts with human, rhesus, and rat ICOS.

TRUSTED_SUSTAINABILITY

Specifications

Antigen ICOS (CD278)
Applications Flow Cytometry
Classification Monoclonal
Clone 398.4A
Conjugate R718
Host Species Armenian Hamster
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Refrigerate Upon Arrival
Form Liquid
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