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ICOS (CD278) Armenian Hamster, anti-Human, R718, Clone: C398.4A, BD Horizon™

Armenian Hamster Monoclonal Antibody

Manufacturer:  BD Biosciences 566990

Catalog No. BDB566990


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Description

Description

The C398.4A monoclonal antibody specifically binds to Inducible Costimulator (ICOS), which is also known as, CD278, Activation-inducible lymphocyte immunomediatory molecule (AILIM), or H4. ICOS is a type I transmembrane glycoprotein that forms a disulfide-linked homodimer and belongs to the CD28 family within the Ig superfamily. ICOS is expressed on either CD4+ or CD8+ single-positive mature thymocytes, T cells, or subsets of Innate Lymphoid Cells (ILC). Its expression is upregulated on activated T lymphocytes. ICOS is a costimulatory receptor that can bind to the B7-H2 ligand (CD275, ICOS-L) that is expressed on B cells, monocytes, macrophages, dendritic cells, and endothelial cells. ICOS plays a critical role in many types of T cell-dependent immunity. In the case of humoral immunity, for example, ICOS signaling is critical for the differentiation of T follicular helper (Tfh) cells and development of germinal centers. Although C398.4A was generated against mouse ICOS, this antibody reportedly crossreacts with human, rhesus, and rat ICOS.

Specifications

Specifications

ICOS (CD278)
C398.4A
Liquid
100 μg
Refrigerate Upon Arrival
Monoclonal
Flow Cytometry
R718
Armenian Hamster
RUO
Primary
Human
SDS
Documents
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