ICP27 Rabbit anti-Virus, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 101861AP150UL

Catalog No. 50-172-6091

Description

There are two serotypes of the herpes simplex virus, HSV-1 (also known as type 1 or oral) and HSV-2 (type 2 or genital), can establish lifelong latent infections within sensory ganglia. Periodically, the virus reactivates and can cause re-current cold sores, eye and genital infections and encephalitis. One of the HSV-1/2 proteins involved in converting the cell into an efficient producer of viral gene products is the Infected Cell Polypeptide 27 or ICP27. HSV-1/2 immediate-early protein ICP27 is a nuclear phosphoprotein that is required for viral growth during lytic infection. Analysis of viral mutants defective in this function has shown that ICP27 has a number of effects on gene expression including a contribution to the shut off of host protein synthesis, the stimulation of HSV-1/2 early gene expression and DNA replication, and the induction of late viral gene products. ICP27 performs these functions primarily post-transcriptionally at the level of RNA processing. ICP27 affects three important RNA processing events: polyadenylation, splicing and nuclear RNA export.

Specifications

• Antigen: ICP27
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Alias: ICP27, Immediate-early protein IE63, Infected cell protein 27, mRNA export factor, UL54, VMW63
• Immunogen: ICP27 Fusion Protein Ag0239
• Quantity: 150 μL
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Form: Liquid

• Applications: ELISA
• Concentration: 0.4 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG