Invitrogen™ ICSA Polyclonal Antibody

Catalog No.	Quantity
FEPA5144412	100 μL

Catalog No. FEPA5144412 Supplier Invitrogen™ Supplier No. PA5144412

Description

Rabbit Polyclonal Antibody

ICSA Polyclonal Antibody for Western Blot, ELISA

An immunogenic protein essential for bacterial spreading, it elicits polar deposition of filamentous actin (actin-based motility) (PubMed:2542950, PubMed:8702989). Inside the host (human) cell mediates nucleation and polymerization of actin molecules on the bacterial surface, which provides the propulsive force for intracellular movement and intercellular dissemination of the bacterium (PubMed:2644195, PubMed:8468279, PubMed:2542950). During invasion of mammalian cells, triggers autophagy by binding to host ATG5. Interaction with IcsB leads to escape from the host autophagy defense system (PubMed:15576571). Binds ATP and displays weak ATPase activity (PubMed:8468279). Mediates polar adhesion to host cells and their invasion. The bile salt deoxycholate activates adhesion and invasion of host cells, possibly by altering IcsA's conformation. The adhesion and intercellular dissemination phenotypes can be separated (PubMed:24721572).

Specifications

• Antigen: ICSA
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 1.745 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.03% Proclin 300; pH 7.4
• Gene: icsA
• Gene Accession No.: Q7BCK4
• Gene Alias: virG
• Gene Symbols: icsA
• Host Species: Rabbit
• Immunogen: Recombinant Shigella flexneri ICSA protein (311-547aa).
• Purification Method: Protein G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1238021
• Target Species: Bacteria
• Content And Storage: -20°C or -80°C if preferred
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG