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Tocris Bioscience™ Idasanutlin
GREENER_CHOICE

Catalog No. 690450
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Potent MDM2 inhibitor; inhibits MDM2-p53 interaction

Idasanutlin is a potent MDM2 inhibitor (IC50 = 6 nM in binding assay, and 30 nM in cancer cell proliferation assay). Induces p53 stabilisation, cell cycle arrest and apoptosis in cancer cells expressing wildtype p53. Displays inhibition of tumor growth in the SJSA1 tumor xenograft model. Also inhibits MDR-1 at high concentrations.

Specifications

Quantity 50 mg
Molecular Formula C31H29Cl2F2N3O4
Formula Weight 616.49
Product Type Inhibitor
Purity 98%
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