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IDH1 Mouse anti-Human, HRP, Clone: OTI2H9, liquid, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA400009

Encompass_Preferred

Catalog No. 50-167-1297


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Description

Description

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predomitly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.
Specifications

Specifications

IDH1
Monoclonal
1 mg/mL
PBS with 0.1% BSA, 50% glycerol and 0.02% sodium azide
O75874
IDH1
Full-length protein expressed in 293T cell transfected with human IDH1 expression vector
100 μL
Primary
Human
Antibody
IgG1
Western Blot
OTI2H9
HRP
IDH1
HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD
Mouse
Affinity Chromatography
RUO
3417
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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