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IDH1 Mouse anti-Human, HRP, Clone: OTI2H9, liquid, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene TA400009

Description
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predomitly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.Specifications
IDH1 | |
Monoclonal | |
1 mg/mL | |
PBS with 0.1% BSA, 50% glycerol and 0.02% sodium azide | |
O75874 | |
IDH1 | |
Full-length protein expressed in 293T cell transfected with human IDH1 expression vector | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG1 |
Western Blot | |
OTI2H9 | |
HRP | |
IDH1 | |
HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD | |
Mouse | |
Affinity Chromatography | |
RUO | |
3417 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
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