IDH1 Mouse anti-Human, HRP, Clone: OTI2H9, liquid, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene TA400009

Catalog No. 50-167-1297

Description

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predomitly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.

Specifications

• Antigen: IDH1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O75874
• Gene Symbols: IDH1
• Immunogen: Full-length protein expressed in 293T cell transfected with human IDH1 expression vector
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI2H9
• Conjugate: HRP
• Gene: IDH1
• Gene Alias: HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3417
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid